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Epitalon (Epithalon)
Also known as: Epithalon, Epithalone, AEDG Peptide
Confidence
Updated 2026-03-18
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied primarily by Russian researcher Professor Vladimir Khavinson for its potential telomerase-activating and anti-aging properties. It is one of the more speculative peptides in the longevity space, with most data coming from Russian research institutions.
Class
Anti-Aging
Routes
Subcutaneous, Intramuscular, Intranasal
Half-Life
Not established.
Proposed to activate telomerase, the enzyme responsible for maintaining telomere length at the ends of chromosomes. Telomere shortening is associated with aging and cellular senescence. Additionally reported to regulate melatonin and cortisol production, potentially influencing circadian rhythm and stress responses.
Half-Life
Not established.
Bioavailability
Not established.
No approved indications. Research: anti-aging, telomere maintenance, melatonin regulation, immune support.
Primarily studied by Khavinson and colleagues at the Saint Petersburg Institute of Bioregulation and Gerontology. Published studies report telomerase activation in human cell cultures and potential lifespan extension in animal models. Western peer review of this data is limited. No RCTs in Western medical literature.
Human Studies
5
Animal Studies
15
Limited safety data. Theoretical concern: telomerase activation could theoretically promote cancer cell immortalization. No validated human safety profile.
FDA Category 2. Prohibited from compounding. Research base primarily Russian, limiting Western regulatory consideration.
Recent Regulatory Activity
Drug Interactions: Unknown. Research Gaps: Telomerase activation is a double-edged sword — anti-aging potential vs. cancer promotion risk. Needs rigorous, independent replication of Russian findings.
Subcutaneous (research context)
Common Range
5–10 mg/day
Timing
Evening
Frequency
Daily during cycle
Cycling
10–20 day cycles, 2–3x per year
Important Note
NOT FDA-approved. Research dosing from Russian studies only.
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Tissue Repair / Anti-Aging
GHK-Cu is a naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine. Levels decline significantly with age (from ~200 ng/mL at age 20 to ~80 ng/mL at age 60). It has gained attention for its broad biological activities including wound healing, anti-inflammatory effects, collagen synthesis, and potential gene expression modulation.
Metabolic / Exercise Mimetic
MOTS-c is a 16-amino acid peptide encoded by mitochondrial DNA — making it one of the few known mitochondrial-derived peptides (MDPs) with signaling functions. Often described as an "exercise mimetic," it plays a key role in metabolic regulation, glucose homeostasis, and cellular energy production. It represents a frontier area of peptide research connecting mitochondrial biology to metabolic health.
Disclaimer: This content is for educational and informational purposes only and does not constitute medical advice. Always consult with a licensed healthcare provider before starting, stopping, or modifying any peptide therapy. PeptideSupplierMatch does not prescribe, sell, or distribute peptides.
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