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Copper Peptide GHK-Cu
Also known as: GHK Copper, Copper Tripeptide-1
Confidence
Updated 2026-03-18
GHK-Cu is a naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine. Levels decline significantly with age (from ~200 ng/mL at age 20 to ~80 ng/mL at age 60). It has gained attention for its broad biological activities including wound healing, anti-inflammatory effects, collagen synthesis, and potential gene expression modulation.
Class
Tissue Repair / Anti-Aging
Routes
Topical, Subcutaneous
Half-Life
Short (minutes) — rapidly degraded after systemic administration
GHK-Cu delivers copper ions to tissues, activating metalloproteinases and stimulating collagen and glycosaminoglycan synthesis. It promotes wound healing, attracts immune cells, stimulates angiogenesis, and has demonstrated ability to modulate the expression of approximately 4,000 human genes — potentially resetting gene expression toward a healthier pattern.
Half-Life
Short (minutes) — rapidly degraded after systemic administration
Bioavailability
Topical: good skin penetration. Systemic: limited by rapid degradation.
Topical: skin rejuvenation, wound healing, anti-aging skin care. Research: systemic anti-aging, hair growth, tissue repair.
Strong evidence for topical wound healing and skin anti-aging effects. Gene expression modulation data is compelling but primarily from in vitro studies. Limited human clinical data for systemic (injectable) use.
Human Studies
15
Animal Studies
30
Topical: well-tolerated, minimal adverse effects. Injectable: limited safety data. Copper toxicity is a theoretical concern with excessive dosing.
Category 1 for topical compounding only. Injectable use not covered by Category 1 status.
Recent Regulatory Activity
Drug Interactions: Minimal known interactions for topical use. Monitoring: Copper levels if used systemically. Research Gaps: Systemic effects in humans not well-characterized.
Topical
Common Range
1–2% concentration in cream or serum
Timing
Morning and/or evening
Frequency
Daily
Cycling
Continuous use
Important Note
Topical is the only legally compoundable route. Applied to face, neck, or treatment area.
Connect with a verified provider offering GHK-Cu therapy near you.
Tissue Repair & Regeneration
BPC-157 is a synthetic pentadecapeptide derived from a protective protein found in human gastric juice. It has generated extraordinary interest for its broad cytoprotective and regenerative effects observed in preclinical studies across virtually every organ system studied. Despite this promise, it remains one of the most controversial peptides due to the near-complete absence of human clinical trial data.
Tissue Repair & Regeneration
TB-500 is a synthetic version of thymosin beta-4, a naturally occurring 43-amino acid protein fragment that plays critical roles in tissue repair, cell migration, and anti-inflammatory processes. Combined with BPC-157, it forms what is colloquially known as "the Wolverine stack" in regenerative wellness circles. Like BPC-157, its clinical evidence base is limited to preclinical data.
Disclaimer: This content is for educational and informational purposes only and does not constitute medical advice. Always consult with a licensed healthcare provider before starting, stopping, or modifying any peptide therapy. PeptideSupplierMatch does not prescribe, sell, or distribute peptides.
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