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Bremelanotide (PT-141)
Also known as: Bremelanotide, Vyleesi
Confidence
Updated 2026-03-18
PT-141 (bremelanotide) is a melanocortin receptor agonist FDA-approved as Vyleesi for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. It is unique among sexual health therapeutics in that it acts centrally through the nervous system rather than peripherally on blood flow.
Class
Sexual Health
Routes
Subcutaneous
Half-Life
~2.7 hours
Activates melanocortin-4 receptors (MC4R) in the central nervous system, specifically in areas of the brain involved in sexual arousal and desire. This central mechanism distinguishes it from PDE5 inhibitors (Viagra, Cialis) which act on peripheral blood flow.
Half-Life
~2.7 hours
Bioavailability
Subcutaneous: ~100%
FDA-approved: HSDD in premenopausal women. Off-label: male sexual dysfunction, female sexual dysfunction beyond HSDD.
Phase III RECONNECT trials demonstrated statistically significant improvement in sexual desire and reduction in distress related to low sexual desire. Modest effect sizes. First centrally-acting medication approved for female sexual dysfunction.
Human Studies
20
Animal Studies
30
Common: nausea (40%), flushing, headache, injection site reactions. Transient blood pressure elevation. Contraindicated in uncontrolled hypertension. Limited to 8 doses per month per FDA label.
FDA-approved (Vyleesi, 2019). Can also be compounded under 503A as a component of an FDA-approved drug.
Drug Interactions: Caution with antihypertensives due to BP effects. Monitoring: Blood pressure. Research Gaps: Limited data in men and postmenopausal women. Long-term use patterns not well-studied.
Subcutaneous
Common Range
1.75 mg per dose
Timing
≥45 minutes before anticipated sexual activity
Frequency
As needed; max 8 doses/month
Cycling
As needed — not daily dosing
Important Note
FDA-approved dose is 1.75mg. Do not use more than one dose in 24 hours or 8 doses per month.
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Disclaimer: This content is for educational and informational purposes only and does not constitute medical advice. Always consult with a licensed healthcare provider before starting, stopping, or modifying any peptide therapy. PeptideSupplierMatch does not prescribe, sell, or distribute peptides.
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