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Ipamorelin Acetate
Also known as: Ipamorelin, IPA
Confidence
Updated 2026-03-18
Ipamorelin is a selective growth hormone secretagogue that mimics ghrelin to stimulate GH release from the pituitary. It is considered one of the most selective GH secretagogues, with minimal effect on cortisol, prolactin, and other hormones — making it a preferred choice in combination protocols with CJC-1295.
Class
GH Secretagogue
Routes
Subcutaneous
Half-Life
~2 hours
Ipamorelin binds to the ghrelin/GHS receptor (GHSR) on pituitary somatotrophs, stimulating GH release in a dose-dependent manner. Unlike other ghrelin mimetics (GHRP-6, GHRP-2), ipamorelin does not significantly increase cortisol, ACTH, or prolactin at therapeutic doses, giving it a cleaner hormonal profile.
Half-Life
~2 hours
Bioavailability
Not formally established. Estimated moderate subcutaneous absorption.
No approved indications. Research areas: growth hormone optimization, anti-aging, sleep improvement, recovery enhancement, body composition.
Human pharmacodynamic studies confirm selective GH stimulation without cortisol or prolactin elevation. Limited clinical outcome data beyond biomarker changes. Well-characterized pharmacology from early development as a pharmaceutical candidate.
Human Studies
12
Animal Studies
30
Generally well-tolerated in available human data. Common: headache, flushing. Rare: nausea, water retention. Advantage: does not elevate cortisol, prolactin, or appetite (unlike GHRP-6).
PCAC rejected inclusion on 503A list (December 2024). Prohibited from routine compounding.
Drug Interactions: Theoretical interaction with glucose-lowering medications. Monitoring: IGF-1 levels. Research Gaps: No large-scale RCTs. Long-term safety data limited.
Subcutaneous (research context)
Common Range
200–300 mcg/dose
Timing
Before bed (fasted)
Frequency
1–3x daily
Cycling
8–12 weeks on, 4 weeks off
Reconstitution
Bacteriostatic water
Storage
Refrigerated
Important Note
Often combined with CJC-1295 (no DAC). NOT FDA-approved.
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GH Secretagogue
CJC-1295 is a synthetic analog of GHRH(1-29) with modifications to extend its half-life. Available in two forms: with Drug Affinity Complex (DAC) for prolonged action, and without DAC (also called Modified GRF 1-29) for shorter, more pulsatile action. Frequently combined with ipamorelin for synergistic GH release.
GHRH Analog
Sermorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) consisting of the first 29 amino acids of the 44-amino acid GHRH sequence. Originally FDA-approved for diagnostic use in assessing growth hormone secretion, it has become a cornerstone of legitimate peptide therapy for growth hormone optimization due to its established safety profile and compounding eligibility.
GHRH Analog
Tesamorelin is a synthetic GHRH analog that is the only FDA-approved peptide therapy specifically for the reduction of excess abdominal fat. Originally approved for HIV-associated lipodystrophy, it has gained significant attention in the anti-aging and metabolic optimization space as a legal, well-characterized GH secretagogue.
Disclaimer: This content is for educational and informational purposes only and does not constitute medical advice. Always consult with a licensed healthcare provider before starting, stopping, or modifying any peptide therapy. PeptideSupplierMatch does not prescribe, sell, or distribute peptides.
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